Detalhe da pesquisa
1.
Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models.
J Pharmacol Exp Ther;
378(2): 70-76, 2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33986036
2.
Endogenous N-acyl taurines regulate skin wound healing.
Proc Natl Acad Sci U S A;
113(30): E4397-406, 2016 07 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27412859
3.
Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation.
Crit Rev Biochem Mol Biol;
51(1): 7-14, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26585314
4.
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.
FASEB J;
29(6): 2616-27, 2015 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25757568
5.
Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive.
Pharmacol Res;
97: 7-15, 2015 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25882247
6.
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Pharmacol Res;
65(5): 553-63, 2012 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22420940
7.
Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor.
Glia;
58(14): 1710-26, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20629190
8.
Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice.
J Neurochem;
114(4): 1143-57, 2010 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20524966
9.
The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis.
J Invest Dermatol;
138(3): 562-569, 2018 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29054595
10.
Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.
Eur J Pharmacol;
566(1-3): 117-9, 2007 Jul 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17434479
11.
A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.
ChemMedChem;
11(12): 1242-51, 2016 06 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26486424
12.
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.
Eur J Med Chem;
109: 216-37, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26774927
13.
Peripheral gating of pain signals by endogenous lipid mediators.
Nat Neurosci;
17(2): 164-74, 2014 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24473264
14.
A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity.
ACS Chem Biol;
9(2): 398-404, 2014 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24191663
15.
Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models.
Pain;
154(3): 350-360, 2013 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23218523
16.
Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain.
Pain;
153(1): 33-41, 2012 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21890273
17.
A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
Nat Neurosci;
15(1): 64-9, 2011 Nov 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22101642
18.
Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice: involvement of allopregnanolone biosynthesis.
Eur Neuropsychopharmacol;
20(3): 195-206, 2010 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19864116
19.
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
J Med Chem;
52(12): 3794-800, 2009 Jun 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19459639
20.
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.
Eur J Pharmacol;
613(1-3): 54-9, 2009 Jun 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19386271